Dr Emma Bimpson and Dr Kesia Reeve discuss the unique and profound challenges that COVID-19 is likely to pose to mothers experiencing homelessness. Last year we completed a research study exploring the experiences of homeless mothers for the UK Collaborative Centre for Housing Evidence (CaCHE) and Sheffield Hallam University. Now that we are all adjusting to a life spent entirely at ‘home’ we have had cause to think about the mothers who participated in that research. It is difficult to imagine what the domestic circumstances described by those women – in the lead up to their homelessness and then afterwards – would look like in the context of COVID-19.